Cell types

  • Permanent – lack significant regenerative potential
    • Remain in G0, regenerate from stem cells.
    • Neurons, skeletal and cardiac muscle, RBCs.
  • Stable (quiescent)
    • Enter G1 from G0 when stimulated.
    • Hepatocytes – Regeneration of liver by compensatory hyperplasia after partial resection. Each hepatocyte produces additional cells
    • Lymphocytes,
    • Proximal convoluted tubule of the kidney
    • Periosteal cells.
  • Labile
    • Never go to G0, divide rapidly with a short G1.
    • Most affected by chemotherapy.
    • Bone marrow (hematopoietic stem cells with CD34)
    • Gut epithelium (stem cells in mucosal crypts)
  • Skin (stem cells in basal layer), hair follicles, germ cells.

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