De Novo Purine and Pyrimidine Synthesis

Various immunosuppressive, antineoplastic, and antibiotic drugs function by interfering with nucleotide synthesis:

  • Pyrimidine synthesis:
    • Leflunomide: inhibits dihydroorotate dehydrogenase
    • Methotrexate (MTX), trimethoprim (TMP), and pyrimethamine: inhibit dihydrofolate reductase (deoxythymidine monophosphate [dTMP]) in humans, bacteria, and protozoa, respectively
    • 5-fluorouracil (5-FU) and its prodrug capecitabine: form 5-F-dUMP, which inhibits thymidylate synthase (dTMP)
  • Purine synthesis:
    • 6-mercaptopurine (6-MP) and its prodrug azathioprine: inhibit de novo purine synthesis
    • Mycophenolate and ribavirin: inhibit inosine monophosphate dehydrogenase
  • Purine and pyrimidine synthesis:
    • Hydroxyurea: inhibits ribonucleotide reductase

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.


Like Us On Facebook

Facebook Pagelike Widget

You cannot copy the contents of this page.