Catecholamine Synthesis and Tyrosine Catabolism

  • Tyrosine to DOPA by tyrosine hydroxylase is rate-limiting.
  • Norepinephrine is converted in the adrenal medulla to epinephrine by phenylethanolamine-N-methyltransferase, which is upregulated by cortisol. Pituitary resection will lead to loss of ACTH, Cortisol & subsequent reduced epinephrine levels.
  • Epinephrine is converted to metanephrine by COMT.
  • Metanephrine & normetanephrine are converted by monoamine oxidase (MAO) to vanillylmandelic acid.

 

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.

TERMS OF SERVICE
ADVERTISE
administrator@filipinomd.com

Like Us On Facebook

Facebook Pagelike Widget

You cannot copy the contents of this page.