• Glycogen
    • Branches have α-(1,6) bonds; linkages have α-(1,4) bonds.
  • Skeletal muscle
    • Glycogen undergoes glycogenolysis → glucose-1-phosphate → glucose-6-phosphate, which is rapidly metabolized during exercise.
  • Hepatocytes
    • Glycogen is stored and undergoes glycogenolysis to maintain blood sugar at appropriate levels.
      • Glycogen phosphorylase (4) liberates glucose-1-phosphate residues off branched glycogen until 4 glucose units remain on a branch.
      • Then 4-α-d-glucanotransferase (debranching enzyme[5]) moves 3 of the 4 glucose units from the branch to the linkage.
      • Then α-1,6-glucosidase (debranching enzyme [6]) cleaves off the last residue, liberating glucose.
    • “Limit dextrin” refers to the one to four residues remaining on a branch after glycogen phosphorylase has already shortened it.
    • Note: A small amount of glycogen is degraded in lysosomes by α-1,4-glucosidase (acid maltase).

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.


Like Us On Facebook

Facebook Pagelike Widget

You cannot copy the contents of this page.