Ketone Bodies

  • In the liver, fatty acids and amino acids are metabolized to acetoacetate and β-hydroxybutyrate (to be used in muscle and brain).
  • In prolonged starvation and diabetic ketoacidosis, oxaloacetate is depleted for gluconeogenesis. In alcoholism, excess NADH shunts oxaloacetate to malate. Both processes cause a buildup of acetyl-CoA, which shunts glucose, amino acids, and FFAs toward the production of ketone bodies.
  • Ketone bodies: acetone, acetoacetate, β-hydroxybutyrate.
  • Breath smells like acetone (fruity odor).
  • Urine test for ketones can detect acetoacetate, but not β-hydroxybutyrate.
  • RBCs cannot utilize ketones; they strictly use glucose.
  • HMG-CoA lyase for ketone production.
  • HMG-CoA reductase for cholesterol synthesis.

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.


Like Us On Facebook

Facebook Pagelike Widget

You cannot copy the contents of this page.