• An alternative method of trapping glucose in the cell is to convert it to its alcohol counterpart, sorbitol, via aldose reductase. Some tissues then convert sorbitol to fructose using sorbitol dehydrogenase; tissues with an insufficient amount/activity of this enzyme are at risk of intracellular sorbitol accumulation, causing osmotic damage (eg, cataracts, retinopathy, and peripheral neuropathy seen with chronic hyperglycemia in diabetes).
  • High blood levels of galactose also result in conversion to the osmotically active galactitol via aldose reductase.
  • Liver, Ovaries, and Seminal vesicles have both enzymes (they LOSe sorbitol).
  • Lens has primarily aldose reductase. Retina, Kidneys, and Schwann cells have only aldose reductase (LuRKS).

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.


You cannot copy the contents of this page.