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TCA cycle (Krebs cycle)

  • Pyruvate → acetyl-CoA produces 1 NADH, 1 CO2.
  • The TCA cycle produces 3 NADH, 1 FADH2, 2 CO2, 1 GTP per acetyl-CoA = 10 ATP/acetyl-CoA (2× everything per glucose).
  • TCA cycle reactions occur in the mitochondria.
  • α-ketoglutarate dehydrogenase complex requires the same cofactors as the pyruvate dehydrogenase complex (B1, B2, B3, B5, lipoic acid).
  • Citrate Is Krebs’ Starting Substrate For Making Oxaloacetate.

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