Vitamin C

  • Also called ascorbic acid.
  • Function
    • Antioxidant; also facilitates iron absorption by reducing it to Fe2+ state.
      • Pronounce “absorbic” acid.
      • Ancillary treatment for methemoglobinemia by reducing Fe3+ to Fe2+.
    • Necessary for hydroxylation of proline and lysine in collagen synthesis.
    • Necessary for dopamine β-hydroxylase, which converts dopamine to NE.
  • Found in fruits and vegetables.
  • Deficiency
    • Scurvy—swollen gums, bruising, petechiae, hemarthrosis, anemia, poor wound healing, perifollicular and subperiosteal hemorrhages, “corkscrew” hair.
    • Weakened immune response.
    • Vitamin C deficiency causes sCurvy due to a Collagen synthesis defect.
  • Excess
    • Nausea, vomiting, diarrhea, fatigue, calcium oxalate nephrolithiasis (increases calcium absorption?.
    • Can ↑ iron toxicity in predisposed individuals by increasing dietary iron absorption (ie, can worsen hereditary hemochromatosis or transfusion-related iron overload).

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