Autoantibodies

AUTOANTIBODY ASSOCIATED DISORDER
Anti-ACh receptor Myasthenia gravis
Anti-presynaptic voltage-gated calcium channel Lambert-Eaton myasthenic syndrome
Anti-β2 glycoprotein Antiphospholipid syndrome
Antinuclear (ANA) Nonspecific screening antibody, often associated with SLE
Anticardiolipin, lupus anticoagulant, antiphospholipid antibodies SLE, antiphospholipid syndrome
Anti-dsDNA, anti-Smith SLE
Anti-histone Drug-induced lupus
Anti-U1 RNP (ribonucleoprotein) Mixed connective tissue disease
Rheumatoid factor (IgM antibody against IgG Fc region), anti-CCP (more specific) Rheumatoid arthritis
Anti-Ro/SSA, anti-La/SSB Sjögren syndrome
Anti-Scl-70 (anti-DNA topoisomerase I) Scleroderma (diffuse)
Anticentromere Limited scleroderma (CREST syndrome)
Antisynthetase (eg, anti-Jo-1), anti-SRP, anti-helicase (anti-Mi-2) Polymyositis, dermatomyositis
Antimitochondrial 1° biliary cirrhosis 1° biliary cholangitis
Anti-smooth muscle Autoimmune hepatitis type 1
MPO-ANCA/p-ANCA Microscopic polyangiitis, eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome), ulcerative colitis
PR3-ANCA/c-ANCA Granulomatosis with polyangiitis (Wegener)
Anti-phospholipase A2 receptor 1° membranous nephropathy
Anti-hemidesmosome Bullous pemphigoid
Anti-desmoglein (anti-desmosome) Pemphigus vulgaris
Antimicrosomal, antithyroglobulin, antithyroid peroxidase Hashimoto thyroiditis
Anti-TSH receptor Graves disease
IgA anti-endomysial, IgA anti-tissue transglutaminase, IgA and IgG deamidated gliadin peptide Celiac disease
Anti-glutamic acid decarboxylase, islet cell cytoplasmic antibodies Type 1 diabetes mellitus
Antiparietal cell, anti-intrinsic factor Pernicious anemia
Anti-glomerular basement membrane Goodpasture syndrome

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