|Allergic/anaphylactic reaction||Type I hypersensitivity reaction against plasma proteins in transfused blood. IgA-deficient individuals must receive blood products without IgA.||Urticaria, pruritus, fever, wheezing, hypotension, respiratory arrest, shock.||Within minutes to 2–3 hours|
|Febrile nonhemolytic transfusion reaction||Two known mechanisms: type II hypersensitivity reaction with host antibodies against donor HLA and WBCs; and induced by cytokines that are created and accumulate during the storage of blood products.||Fever, headaches, chills, flushing.||Within 1–6 hours|
|Acute hemolytic transfusion reaction||Type II hypersensitivity reaction.
Intravascular hemolysis (ABO blood group incompatibility) or extravascular hemolysis (host antibody reaction against foreign antigen on donor RBCs).
|Fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinuria (intravascular hemolysis), jaundice (extravascular).||Within 1 hour|
|Transfusion-related acute lung injury||Donor anti-leukocyte antibodies against recipient neutrophils and pulmonary endothelial cells.||Respiratory distress and noncardiogenic pulmonary edema.||Within 6 hours|