Calcineurin

In normal T cells, calcineurin is a protein phosphatase that is activated upon stimulation of the appropriate cell receptor.  Once activated, calcineurin dephosphorylates nuclear factor of activated T cells (NFAT), which allows NFAT to enter the nucleus and bind to an interleukin-2 (IL-2) promoter.  IL-2 stimulates the growth and differentiation of T cells and is an important component of the immune response.

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