| PATHOGEN | LOW T CELLS | LOW B CELLS | LOW GRANULOCYTES | LOW COMPLEMENT |
| Bacteria | Sepsis | Encapsulated (Please SHINE SKiS):
Pseudomonas aeruginosa, Streptococcus pneumoniae, Haemophilus Influenzae type b, Neisseria meningitidis, Escherichia coli, Salmonella, Klebsiella pneumoniae, Group B Streptococcus |
Staphylococcus,
Burkholderia cepacia, Pseudomonas aeruginosa, Serratia, Nocardia |
Encapsulated species with early complement deficiencies
Neisseria with late complement (C5–C9) deficiencies |
| Viruses | CMV, EBV, JC virus, VZV, chronic infection with respiratory/GI viruses | Enteroviral encephalitis, poliovirus (live vaccine contraindicated) | N/A | N/A |
| Fungi/parasites | Candida (local), PCP, Cryptococcus | GI giardiasis (no IgA) | Candida (systemic), Aspergillus, Mucor | N/A |
Note: B-cell deficiencies tend to produce recurrent bacterial infections, whereas T-cell deficiencies produce more fungal and viral infections.