Infections in Immunodeficiency

PATHOGEN LOW T CELLS LOW B CELLS LOW GRANULOCYTES LOW COMPLEMENT
Bacteria Sepsis Encapsulated (Please SHINE SKiS):

Pseudomonas aeruginosa,

Streptococcus pneumoniae,

Haemophilus Influenzae type b,

Neisseria meningitidis,

Escherichia coli,

Salmonella,

Klebsiella pneumoniae,

Group B Streptococcus

Staphylococcus,

Burkholderia cepacia,

Pseudomonas aeruginosa,

Serratia,

Nocardia

Encapsulated species with early complement deficiencies

Neisseria with late complement (C5–C9) deficiencies

Viruses CMV, EBV, JC virus, VZV, chronic infection with respiratory/GI viruses Enteroviral encephalitis, poliovirus (live vaccine contraindicated) N/A N/A
Fungi/parasites Candida (local), PCP, Cryptococcus GI giardiasis (no IgA) Candida (systemic), Aspergillus, Mucor N/A

Note: B-cell deficiencies tend to produce recurrent bacterial infections, whereas T-cell deficiencies produce more fungal and viral infections.

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