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Interferon-α and -β

  • A part of innate host defense against both RNA and DNA viruses.
  • Synthesized by leukocytes.
  • Interferons are glycoproteins synthesized by virus-infected cells that act on local cells, “priming them” for viral defense by downregulating protein synthesis to resist potential viral replication and upregulating MHC expression to facilitate recognition of infected cells.
  • Halting protein synthesis, such as RNase L (endonuclease that degrades all RNA in the cell) and protein kinase R (inactivates eIF-2, inhibiting translation initiation)
  • Interfere with viruses.
  • Self-destruct by decreasing supply to reproduce, sending alarms

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