Major Histocompatibility Complex I and II

  • MHC encoded by HLA genes. Present antigen fragments to T cells and bind T-cell receptors (TCRs).
  •   MHC I MHC II
    LOCI HLA-A, HLA-B, HLA-C

    MHC I loci have 1 letter

    HLA-DP, HLA-DQ, HLA-DR

    MHC II loci have 2 letters

    BINDING TCR and CD8 TCR and CD4
    STRUCTURE 1 long chain, 1 short chain 2 equal-length chains (2 α, 2 β)
    EXPRESSION All nucleated cells, APCs, platelets

    Not on RBCs

    APCs
    FUNCTION Present endogenously synthesized antigens (eg, viral or cytosolic proteins) to CD8+ cytotoxic T cells Present exogenously synthesized antigens (eg, bacterial proteins) to CD4+ helper T cells
    ANTIGEN LOADING Antigen peptides loaded onto MHC I in RER after delivery via TAP (transporter associated with antigen processing) Antigen loaded following release of invariant chain in an acidified endosome
    ASSOCIATED PROTEINS β2-microglobulin Invariant chain

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