• Located in LUQ of abdomen, anterior to left kidney, protected by 9th-11th ribs.
  • Sinusoids are long, vascular channels in red pulp (red arrows in A) with fenestrated “barrel hoop” basement membrane.
  • T cells are found in the periarteriolar lymphatic sheath (PALS) within the white pulp (white arrows in A).
  • B cells are found in follicles within the white pulp.
  • The marginal zone, in between the red pulp and white pulp, contains macrophages and specialized B cells, and is where antigen-presenting cells (APCs) capture blood-borne antigens for recognition by lymphocytes.
  • Splenic macrophages remove encapsulated bacteria.
  • Splenic congestion occurs during a splenic sequestration crisis (marked hemoglobin decrease, rapidly enlarging spleen), which develops due to vaso-occlusion within the cords of Billroth and splenic pooling of erythrocytes.
  • Repeated infarction leads to functional asplenia & autosplenectomy (splenic atrophy)
  • Splenic dysfunction (eg, postsplenectomy state in sickle cell disease): ¯ IgM → ¯ complement activation → ¯ C3b opsonization → ­ susceptibility to encapsulated organisms.
  • Postsplenectomy blood findings:
    • Howell-Jolly bodies (nuclear remnants)
    • Target cells
    • Thrombocytosis (loss of sequestration and removal)
    • Lymphocytosis (loss of sequestration)
  • Vaccinate patients undergoing splenectomy against encapsulated organisms (pneumococcal, Hib, meningococcal)
  • Splenic cyst formation typically occurs due to infection.
  • Spleen is prone to rupture during splenomegaly. Avoid contact sports.

Filipino MD

An independent organization catered to bringing enriching opportunities to doctors, researchers and medical institutions.


You cannot copy the contents of this page.